Journal Articles, Conference Proceedings and Book Chapters

  1. Graham RS, Zachs DP, Cotero V, D'Agostino C, Ntiloudi D, Kaiser CRW, Graf J, Wallace K, Ramdeo R, Coleman TR, Ashe J, Pellerito J, Tracey KJ, Binstadt BA, Chavan SS, Zanos S, Puleo C, Peterson E, Lim HH. First-in-human demonstration of splenic ultrasound stimulation for non-invasively controlling inflammation. (posted on medRxiv while in review with a journal)
  2. Conlon B, Hamilton C, Hughes S, Meade E, Hall DA, Vanneste S, Langguth B, Lim HH. Noninvasive bimodal neuromodulation for the treatment of tinnitus: Protocol for a second large-scale double-blind randomized clinical trial to optimize simulation parameters. JMIR Research Protocols 8(9):e13176,2019.
  3. Lenarz T, Samii A, Dyballa KH, Lim HH. Auditory Midbrain Implant In: Auditory Brainstem Implants, edited by Wilkinson EP, Schwartz MS. Published by Thieme Publishers, 2020.
  4. Hosseini, M, Rodriguez G, Guo H, Lim HH, Plourde E. Novel metrics to measure the effect of additive inputs on the activity of sensory system neurons. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society 41, 2019.
  5. Cotero V, Graf J, Zachs DP, Tracey KJ, Ashe J, Lim HH, Puleo C. (2019) Peripheral Focused Ultrasound Stimulation (pFUS): New Competitor in Pharmaceutical Markets? SLAS Technol. 24(4). Article.
  6. Zachs D., Offutt S., Graham R., Kim Y., Mueller J., Auger J., Schuldt N., Kaiser C., Heiller A., Dutta R., Guo H., Alford J., Binstadt B., Lim H. (2019) Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis. Nature Communcations (10). Article.
  7. Stahn P., Lim HH., Hinsberger MP., Sorg K., Pillong L., Kannengieber M., Schreiter C., Foth HG., Langenbucher A., Schick B., Wenzel GI. (2019). Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation. Scientific Reports (9). Article.
  8. Xu, J., Guo, H., Nguyen, A., Lim, H., Yang, Z. (2018). A Bidirectional Neuromodulation Technology for Nerve Recording and Stimulation. Micromachines 9,538. Article
  9. Guo H, Hamilton M, Offutt SJ, Gloeckner CD, Li T, Kim Y, Legon W, Alford JK, Lim HH. "Ultrasound produces extensive brain activation via a cochlear pathway." Neuron, 2018. Article
  10. Xu J, Nguyen AT, Zhao W, Guo H, Wu T, Wiggins H, Keefer E, Lim HH, Yang Z. "A low-noise, wireless, frequency-shaping neural recorder." IEEE Journal on emerging and Selected Topics in Circuits and Systems, 2018. Abstract
  11. Lim HH, Adams ME, Nelson PB, Oxenham AJ. Restoring Hearing with Neural Prostheses: Current Status and Future Directions. In: Neuroprosthetics: Theory and Practice, edited by Horch KW, Kipke DR. Published by World Scientific Publishing Co., 2017.
  12. Wu, T., Zhao, W., Guo, H., Lim, H.H., & Yang, Z. (2017). A Streaming PCA VLSI Chip for Neural Data Compression. IEEE transactions on biomedical circuits and systems. 11(6), 1290-1302. [8010351]. DOI: 10.1109/TBCAS.2017.2717281
  13. Lim HH, Patrick JF, Lenarz T. Current Progress with Auditory Midbrain Implants. In: Scientific Foundations of Audiology, Perspectives from Physics, Biology, Modeling and Medicine, edited by Cacace AT, de Kleine E, Holt AG, van Dijk P. Published by Plural Publishing, Inc., 2016.
  14. Siahpoush S, Erfani Y, Rode T, Lim HH, Rouat J, Plourde E. "Improving neural decoding in the central auditory system using bio-inspired spectro-temporal representations and a generalized bilinear model". 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 37: 5146-5150, 2015.
  15. Lim HH, Shannon RV. "Two Laskers and Counting: Learning From the Past Enables Future Innovations With Central Neural Prostheses." Brain Stimulation, 8(3): 439-41, 2015. Invited Editorial Abstract

  16. Lim HH, Lenarz T. "Auditory Midbrain Implant: Research and development towards a second clinical trial." Hearing Research 322: 212-223, 2015. Abstract

  17. Markovitz CD, Smith BT, Gloeckner CD, Lim HH. "Investigating a new neuromodulation treatment for brain disorders using synchronized activation of multimodal pathways." Scientific Reports 5: 9462, 2015. Abstract

  18. Berding G, Wilke F, Rode T, Haense C, Joseph G, Meyer GJ, Mamach M, Lenarz M, Geworski L, Bengel FM, Lenarz T, Lim HH.  "Positron emission tomography imaging reveals auditory and frontal cortical regions involved with speech perception and loudness adaptation."  PLoS One 10(6): e0128743, 2015. Abstract

  19. Czanner G, Sarma SV, Ba D, Eden UT, Wu W, Eskandar E, Lim HH, Temeranca S, Suzuki WA, Brown EN.  "Measuring the signal-to-noise ratio of a neuron."  Proceedings of the National Academy of Sciences of the USA 112(23): 7141-7146, 2015. Abstract

  20. Plourde E, Rode T, Lim HH.  "A contribution of trained parameters to the goodness of fit of a Bayesian neural encoding model for the auditory system." Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering 7: 910-913, 2015.Abstract

  21. Straka MM, Hughes R, Lee P, Lim HH.  "Descending and tonotopic projection patterns from the auditory cortex to the inferior colliculus."  Neuroscience 300: 325-337, 2015. Abstract

  22. Markovitz CD, Hogan PS, Wesen KA, Lim HH. "Pairing broadband noise with cortical stimulation induces extensive suppression of ascending sensory activity." Journal of Neural Engineering, 12(2), 2015. Abstract

  23. Offutt SJ, Ryan KJ, Konop AE, Lim HH. "Suppression and facilitation of auditory neurons through coordinated acoustic and midbrain stimulation: investigating a deep brain stimulator for tinnitus." Journal of Neural Engineering, 11(6), 2014. Abstract

  24. Straka MM, Schmitz S, Lim HH. "Response features across the auditory midbrain reveal an organization consistent with a dual lemniscal pathway." Journal of Neurophysiology, 112(4): 981-98, 2014. Abstract

  25. Straka MM, McMahon M, Markovitz CD, Lim HH. "Effects of location and timing of co-activated neurons in the auditory midbrain on cortical activity: implications for a new central auditory prosthesis." Journal of Neural Engineering, 11(4), 2014. Abstract

  26. Straka MM, Schendel D, Lim HH. "Neural integration and enhancement from the inferior colliculus up to different layers of auditory cortex." Journal of Neurophysiology, 110(4): 1009-1020, 2013. Abstract

  27. Gloeckner CD, Smith BT, Markovitz CD, Lim HH. "A new concept for non-invasive tinnitus treatment utilizing multimodal pathways." Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 3122-3125, 2013. Abstract

  28. Calixto R, Salamat B, Rode T, Hartmann T, Volckaerts B, Ruther P, Lenarz T, Lim HH. "Investigation of a new electrode array technology for a central auditory prosthesis." PLoS One, 8(12), 2013. Abstract

  29. Rode T, Hartmann T, Hubka P, Scheper V, Lenarz M, Lenarz T, Kral A, Lim HH. "Neural representation in the auditory midbrain of the envelope of vocalizations based on a peripheral ear model." Frontiers in Neural Circuits, 7(166), 2013. Abstract

  30. Markovitz CD, Tang TT, Lim HH. "Tonotopic and localized pathways form primary auditory cortex to the central nucleus of the inferior colliculus."  Frontiers in Neural Circuits, 7(77), 2013. Abstract

  31. Johnson MD, Lim HH, Netoff TI, Connolly AT, Johnson N, Roy A, Holt A, Lim KO, Carey JR, Vitek JL, He B. "Neuromodulation for brain disorders: Challenges and opportunities." IEEE Transactions on Biomedical Engineering, 60(3): 610-624, 2013. Abstract

  32. Lim HH, Lenarz M, Joseph G, Lenarz T. "Frequency representation within the human brain: Stability versus plasticity." Scientific Reports, 3: 1474, 2013. Abstract

  33. McKay CM, Lim HH, Lenarz T. "Temporal processing in the auditory system: Insights form the auditory midbrain implantees." Journal of the Association for Research in Otolaryngology 14: 103-124, 2013. Abstract

  34. Markovitz CD, Tang TT, Edge DP, Lim HH. "Three-dimensional brain reconstruction of in vivo electrode tracks for neuroscience and neural prosthetic applications." Frontiers in Neural Circuits, 6(39), 2012. Abstract

  35. Calixto R, Lenarz M, Neuheiser A, Scheper V, Lenarz T, Lim HH. "Co-activation of different neurons along the isofrequency laminae of the inferior colliculus elicits enhanced cortical activation." Journal of Neurophysiology 108: 1199-1210, 2012. Abstract
  36. Lim HH, Lenarz M, Lenarz T. Midbrain Auditory Prostheses. In: Auditory Prostheses: Cochlear Implants and Beyond, edited by Zeng F-G, Fay RR and Popper AN. Published by Springer as part of the Handbook of Auditory Research, 2011.

  37. Neuheiser A, Lenarz M, Reuter G, Calixto R, Nolte I, Lenarz T, Lim HH. "Effects of pulse phase duration and location of stimulation within the inferior colliculus on auditory cortical evoked potentials in a guinea pig model." Journal of the Association for Research in Otolaryngology 11: 689-708, 2010. Abstract

  38. Zhang K, Wenzel GI, Balster S, Lim HH, Lubatschowski H, Lenarz T, Ertmer W, Reuter G. "Optoacoustic induced vibrations within the inner ear." Optics Express, 17(25): 23037-23043, 2009. Abstract
  39. Lenarz T, Lim HH, Joseph G, Reuter G, Lenarz M. [Central auditory prosthesis]. HNO 57(6): 551-562, 2009. Abstract

  40. Wenzel GI, Balster S, Zhang K, Lim HH, Reich U, Massow O, Lubatschowski H, Ertmer W, Lenarz T, Reuter G. "Green laser light activates the inner ear." Journal of Biomedical Optics, 14(4): 044007, 2009. Abstract
  41. Lim HH, Lenarz M, Lenarz T. Auditory midbrain implant: A review. Trends in Amplification 13(3): 149-180, 2009. Abstract
  42. Lim HH, Lenarz M, Lenarz T. A New Auditory Prosthesis Using Deep Brain Stimulation: Development and Implementation. In: Implantable Neural Prostheses: Techniques and Applications, edited by Zhou D and Greenbaum E. Published by Springer as part of the Biological and Medical Physics: Biomedical Engineering Series, 2009.

  43. Lim HH, Lenarz T, Anderson DJ, Lenarz M. "The Auditory Midbrain Implant: Effects of electrode location." Hearing Research, 242: 74-85, 2008. Abstract

  44. Lim HH, Lenarz T, Joseph G, Battmer RD, Patrick JF, Lenarz M. "Effects of phase duration and pulse rate on loudness and pitch percepts in the first auditory midbrain implant patients: Comparison to cochlear implant and auditory brainstem implant results." Neuroscience, 154(1): 370-380, 2008. Abstract
  45. Lenarz T, Lim HH, Lenarz M. The Auditory Midbrain Implant: Experimental and clinical results. In: Recent Advances in Otolaryngology, edited by Kier J, Moffat DA and Studhoff H. Published by The Royal Society of Medicine Press as part of the Recent Advances Series, 2008.

  46. Czanner G, Dreyer AA, Eden UT, Wirth S, Lim HH, Suzuki WA, Brown EN. "Dynamic models of neural spiking activity." Proceedings of the 46th IEEE Conference on Decision & Control, 5812-5817, 2007.

  47. Lim HH, Lenarz T, Joseph G, Battmer RD, Samii A, Samii M, Patrick JF, Lenarz M. "Electrical stimulation of the midbrain for hearing restoration: Insight into the functional organization of the human central auditory system." Journal of Neuroscience, 27(49): 13541-13551, 2007. Abstract

  48. Lenarz M, Lim HH, Reuter G, Reich U, Marquardt N, Klingberg MN, Paasche G, Lenarz T, Stan A. "Auditory Midbrain Implant: Histomorphological effects of long-term implantation and electrical stimulation of a new DBS array." Otology & Neurotology, 28: 1045-1052, 2007. Abstract

  49. Lim HH, Anderson DJ. "Spatially distinct functional output regions within the central nucleus of the inferior colliculus: Implications for an Auditory Midbrain Implant." Journal of Neuroscience, 27(32): 8733-8743, 2007. Abstract

  50. Lim HH, Anderson DJ. "Antidromic activation reveals tonotopically organized projections from primary auditory cortex to the central nucleus of the inferior colliculus in guinea pig." Journal of Neurophysiology, 97: 1413-1427, 2007. Abstract

  51. Samii A, Lenarz M, Majdani O, Lim HH, Samii M, Lenarz T. "Auditory Midbrain Implant - A combined approach for vestibular schwannoma surgery and device implantation."  Otology & Neurotology, 28: 31-38, 2007. Abstract

  52. Lenarz M, Lim HH, Patrick JF, Anderson DJ, Lenarz T. "Electrophysiological validation of a human prototype auditory midbrain implant (AMI) in a guinea pig model." Journal of the Association for Research in Otolaryngology, 7: 383-398, 2006. Abstract

  53. Lenarz T, Lim HH, Reuter G, Patrick JF, Lenarz M. "The Auditory Midbrain Implant (AMI): A new auditory prosthesis for neural deafness. Concept and device description." Otology& Neurotology, 27: 840-845, 2006. Abstract

  54. Lim HH, Anderson DJ. "Auditory cortical responses to electrical stimulation of the inferior colliculus: Implications for an auditory midbrain implant." Journal of Neurophysiology, 96: 975-988, 2006. Abstract

  55. Lim HH, Anderson DJ. "Feasibility experiments for the development of a midbrain auditory prosthesis." Proceedings of the 1st International IEEE EMBS Conference on Neural Engineering, 193-196, 2003.
  56. Lim HH, DeLano FA, Schmid-Schonbein GW. "Life and death cell labeling in the microcirculation of the spontaneously hypertensive rat". Journal of Vascular Research 38: 228-236, 2001.